2-Chloro-3-fluoro-5-(trifluoromethyl)pyridine synthesis

Yield:72600-67-0 23%

Reaction Conditions:

with HF;SF₄

Steps:

19 2-Chloro-3-fluoro-5-trifluoromethylpyridine

EXAMPLE 19 2-Chloro-3-fluoro-5-trifluoromethylpyridine A steel bomb was charged with 6-chloro-5-fluoronicotinic acid (5.4 g, 0.03 m), SF₄ (32.4 g) and HF (5.6 ml). The mixture was heated at 120° for eight hours. After cooling to 25°, the bomb was vented and the contents poured onto ice. The solution was neutralized with saturated Na₂ CO₃ solution and extracted with CH₂ Cl₂. The organic layer was dried over Na₂ SO₄, filtered and the solvent distilled off on a steam bath. The residue was distilled at 115° (760 mm) to yield 1.4 g (23% yield) of 2-chloro-3-fluoro-5-trifluoromethylpyridine.

References:

US4279913,1981,A