ChemicalBook CAS DataBase List Picoxystrobin

Picoxystrobin synthesis

9synthesis methods

Product Name:Picoxystrobin
CAS Number:117428-22-5
Molecular formula:C18H16F3NO4
Molecular Weight:367.32

34486-06-1
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(E)-3-Methoxy-2-(2-broMoMethylphenyl)propenoic acid Methyl ester

117428-49-6
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117428-22-5
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Yield:117428-22-5 98%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 50; for 24 h;

Steps:

32.4 The fourth step: preparation of picoxystrobin 6
The methoxy acrylate compound 3o (1.0 mmol),6-trifluoromethyl-2-hydroxypyridine (1.3 mmol)And potassium carbonate (2.0 mmol) was added to 5.0 mL of DMF.After reacting for 24 hours in an oil bath at 50 ° C, the reaction was stopped and cooled to room temperature.20 mL of water and 20 mL of ethyl acetate were added to the reaction solution for extraction.The aqueous phase was washed 3 times with 20 mL of ethyl acetate.After combining the organic phases, wash with 20 mL of saturated sodium chloride.The organic phase was dried over anhydrous sodium sulfate. After filtering and evaporating the solvent under reduced pressure,The residue was separated and purified by column chromatography on silica gel.The volume ratio of the eluent used is ethyl acetate: petroleum ether = 1:20 ~ 1:10,The pure picoxystrobin 6 was obtained in a yield of 98%

References:

Chinese Academy Of Sciences Lanzhou Chemical Physics Institute;Huang Hanmin;Qian Bo;Li Jiawen CN108821974, 2018, A Location in patent:Paragraph 0094; 0097

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