ChemicalBook CAS DataBase List 2-Chloro-3-methoxypyridine

2-Chloro-3-methoxypyridine synthesis

7synthesis methods

Product Name:2-Chloro-3-methoxypyridine
CAS Number:52605-96-6
Molecular formula:C6H6ClNO
Molecular Weight:143.57

6636-78-8 Synthesis

6636-78-8
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74-88-4
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52605-96-6
166 suppliers
$6.00/250mg

Yield:52605-96-6 100%

Reaction Conditions:

Stage #1:2-chloro-3-hydroxypyridine with sodium methylate in N,N-dimethyl-formamide at 20; for 0.333333 h;
Stage #2:methyl iodide in N,N-dimethyl-formamide at 20; for 0.666667 h;Cooling with ice;

Steps:

1.1 step 1:
To a three-necked flask were added 2-chloro-3-hydroxypyridine (5.0 g, 39.0 mmol), N, N- dimethylformamide (60 mL); sodium methoxide (2.30 g, 43.0 mmol ). The reaction was stirred at room temperature for 20 minutes. Methyl iodide (8.20 g, 58.0 mmol) was added to the ice bath and stirred at room temperature for 40 minutes. Water (120 mL) was added and extracted with ethyl acetate (100 mL x 3); the organic phases were combined, washed with water (100 mL x 2) and brine (100 mL), dried over sodium sulphate and filtered. The filtrate was spin-dried to give a yellow liquid, compound 1 (5.58 g, 39.0 mmol, 100%) which was used directly in the next reaction;

References:

Kanghua (Shanghai) Drug Discovery Co., Ltd.;Ma Jingxiang CN107286084, 2017, A Location in patent:Paragraph 0008

FullText

74-88-4
341 suppliers
$15.00/10g

52605-96-6
166 suppliers
$6.00/250mg

References