![](/CAS/GIF/55270-71-8.gif)
2-Chloro-4'-hydroxybenzophenone synthesis
- Product Name:2-Chloro-4'-hydroxybenzophenone
- CAS Number:55270-71-8
- Molecular formula:C13H9ClO2
- Molecular Weight:232.66
![2-CHLORO-4'-METHOXYBENZOPHENONE](/CAS/GIF/54118-74-0.gif)
54118-74-0
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![2-Chloro-4'-hydroxybenzophenone](/CAS/GIF/55270-71-8.gif)
55270-71-8
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Yield:55270-71-8 95%
Reaction Conditions:
with aluminum (III) chloride in toluene at 130; for 2 h;Inert atmosphere;
Steps:
1.4. General method for demethylation of 3b, 3d-l and 3n-p with aluminum trichloride (4b, 4d-l and 4n-p).[10]
General procedure: AlCl3 (2.5 equiv.) was slowly added to a solution of 3b, 3d-l and 3n-p (1.0 equiv.) in toluene (0.15 M) under a N2 atmosphere. The mixture was refluxed at 130 °C for 2 h and by TLC (Pet. ether/EtOAc 4/1) full conversion was shown. The cooled mixture was poured into an 3 M HCl (aq.) solution, the organics were extracted with ethyl acetate (3 times), washed with brine, dried over MgSO4 and concentrated to give the desired 4-(benzoyl)phenols (4b, 4d-l and 4n-p) as solids.
References:
Yu, Zhiyi;Van Veldhoven, Jacobus P.D.;'T Hart, Ingrid M.E.;Kopf, Adrian H.;Heitman, Laura H.;Ijzerman, Adriaan P. [European Journal of Medicinal Chemistry,2015,vol. 106,p. 50 - 59] Location in patent:supporting information
![2-Chlorobenzoyl chloride](/CAS/GIF/609-65-4.gif)
609-65-4
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55270-71-8
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![2-Chlorobenzoic acid](/CAS/GIF/118-91-2.gif)
118-91-2
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55270-71-8
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100-66-3
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55270-71-8
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1174327-78-6
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![2-Chloro-4'-hydroxybenzophenone](/CAS/GIF/55270-71-8.gif)
55270-71-8
25 suppliers
$150.50/50mg