(2-Chloro-4-methoxy-phenyl)-methanol synthesis

6synthesis methods

Product Name:(2-Chloro-4-methoxy-phenyl)-methanol
CAS Number:334018-24-5
Molecular formula:C8H9ClO2
Molecular Weight:172.61

54439-75-7 Synthesis

54439-75-7
101 suppliers
$6.00/250mg

334018-24-5
26 suppliers
$45.00/1g

Yield:334018-24-5 97%

Reaction Conditions:

with sodium borohydride in methanol;ethyl acetate;

Steps:

R.21 2-chloro-4-methoxybenzyl alcohol

Reference Example 21 2-chloro-4-methoxybenzyl alcohol To a solution of 2-chloro-4-methoxybenzaldehyde (1.55 g, 9 mmol) in methanol (20 mL) was added under ice-cooling sodium borohydride (378 mg, 10 mmol) and the mixture was stirred atroom temperature for 30 min. The solvent was evaporated under reduced pressure and the obtained residue was dissolved in ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give an almost pure title compound (1.5 g, 97%). ¹H-NMR (δ ppm, CDCl₃): 1.87 (1H, br t, J=6.2 Hz), 3.80 (3H, s), 4.71 (2H, d, J=5.8 Hz), 6.81 (1H, dd, J=2.6, 8.6 Hz), 6.93 (1H, d, J=2.6 Hz), 7.35 (1H, d, J=8.4 Hz)

References:

EP1223170,2002,A1

21971-21-1 Synthesis