ChemicalBook CAS DataBase List 2-Chloro-4-hydroxybenzaldehyde

2-Chloro-4-hydroxybenzaldehyde synthesis

9synthesis methods

Product Name:2-Chloro-4-hydroxybenzaldehyde
CAS Number:54439-75-7
Molecular formula:C8H7ClO2
Molecular Weight:170.59

56962-11-9 Synthesis

56962-11-9
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54439-75-7
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$6.00/250mg

Yield: 70%

Reaction Conditions:

with potassium carbonate in water;N,N-dimethyl-formamide

Steps:

R.20 -chloro-4-methoxybenzaldehyde
Reference Example 20 -chloro-4-methoxybenzaldehyde To a solution of 2-chloro-4-hydroxybenzaldehyde (2 g, 12.8 mmol) in N,N-dimethylformamide (25 mL) were added potassium carbonate (3.46 g, 25 mmol) and methyl iodide (large excess) and the mixture was stirred at room temperature for 18 h. Water was added to the reaction mixture and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give an almost pure title compound (1.55 g, 70%). ¹H-NMR (δ ppm, CDCl₃): 3.89 (3H, s), 6.84-6.95 (2H, m), 7.90 (1H, d, J=8.8 Hz), 10.33 (1H, s)

References:

Takeda Chemical Industries, Ltd. EP1223170, 2002, A1

74-88-4
342 suppliers
$15.00/10g

54439-75-7
102 suppliers
$6.00/250mg

References

123-11-5 Synthesis