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2-CHLORO-5-(4-CHLOROPHENYL)NICOTINONITRILE synthesis
- Product Name:2-CHLORO-5-(4-CHLOROPHENYL)NICOTINONITRILE
- CAS Number:35982-99-1
- Molecular formula:C12H6Cl2N2
- Molecular Weight:249.1
![4-Chlorophenylacetic acid](/CAS/GIF/1878-66-6.gif)
1878-66-6
443 suppliers
$6.00/25g
![2-CHLORO-5-(4-CHLOROPHENYL)NICOTINONITRILE](/CAS/GIF/35982-99-1.gif)
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Yield:-
Steps:
Multi-step reaction with 3 steps
1.1: trichlorophosphate / 6 h / 0 - 75 °C / Inert atmosphere
1.2: 1 h / 100 °C / pH 11
2.1: sodium methylate / methanol / 1 h / 20 °C / Inert atmosphere
2.2: 4 h / Reflux; Inert atmosphere
3.1: trichlorophosphate / 120 - 130 °C / Inert atmosphere
References:
Hogenkamp, Derk J.;Ford-Hutchinson, Thomas A.;Li, Wen-Yen;Whittemore, Edward R.;Yoshimura, Ryan F.;Tran, Minhtam B.;Johnstone, Timothy B. C.;Bascom, Gavin D.;Rollins, Hannah;Lu, Lena;Gee, Kelvin W. [Journal of Medicinal Chemistry,2013,vol. 56,# 21,p. 8352 - 8365]
![Phenylphosphonic dichloride](/CAS/GIF/824-72-6.gif)
824-72-6
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$15.00/25 g
![Ammonium hydroxide](/CAS/GIF/1336-21-6.gif)
1336-21-6
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$14.56/250ML
![5-(4-CHLOROPHENYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE](/CAS/GIF/35982-98-0.gif)
35982-98-0
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![2-CHLORO-5-(4-CHLOROPHENYL)NICOTINONITRILE](/CAS/GIF/35982-99-1.gif)
35982-99-1
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![5-(4-CHLOROPHENYL)-2-OXO-1,2-DIHYDRO-3-PYRIDINECARBONITRILE](/CAS/GIF/35982-98-0.gif)
35982-98-0
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![2-CHLORO-5-(4-CHLOROPHENYL)NICOTINONITRILE](/CAS/GIF/35982-99-1.gif)
35982-99-1
20 suppliers
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