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2-Chloro-5-fluoro-4-thiocyanopyrimidine synthesis
- Product Name:2-Chloro-5-fluoro-4-thiocyanopyrimidine
- CAS Number:112889-53-9
- Molecular formula:C5HClFN3S
- Molecular Weight:189.6
![2,4-Dichloro-5-fluoropyrimidine](/CAS/GIF/2927-71-1.gif)
2927-71-1
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![2-Chloro-5-fluoro-4-thiocyanopyrimidine](/CAS/20180629/GIF/112889-53-9.gif)
112889-53-9
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Yield:112889-53-9 68%
Reaction Conditions:
in formic acid;
Steps:
S.2 Synthesis of 2-chloro 5-fluoro-4-thiocyanopyrimidine (Compound No. 2)
SYNTHESIS EXAMPLE 2 Synthesis of 2-chloro 5-fluoro-4-thiocyanopyrimidine (Compound No. 2) In 50 ml of formic acid, a reaction of 10.0 g of 2,4-dichloro-5-fluoropyrimidine and 5.8 g of potassium thiocyanate was conducted at room temperature (20° C.) for 5 hours in a similar manner as Synthesis Example 1. Then, the reaction mixture was treated in a similar procedure as Synthesis Example 1, there was obtained a 68.0% yield of 2-chloro-5-fluoro-4-thiocyanopyrimidine, m.p. 103°-104° C. NMR (DMSO-d6) δ=8.85 ppm (s). IR (KBr): 2180 cm-1 (-SCN)
References:
US4814337,1989,A