2-Chloro-5-fluoro-4-thiocyanopyrimidine synthesis

Yield:112889-53-9 68%

Reaction Conditions:

in formic acid;

Steps:

S.2 Synthesis of 2-chloro 5-fluoro-4-thiocyanopyrimidine (Compound No. 2)

SYNTHESIS EXAMPLE 2 Synthesis of 2-chloro 5-fluoro-4-thiocyanopyrimidine (Compound No. 2) In 50 ml of formic acid, a reaction of 10.0 g of 2,4-dichloro-5-fluoropyrimidine and 5.8 g of potassium thiocyanate was conducted at room temperature (20° C.) for 5 hours in a similar manner as Synthesis Example 1. Then, the reaction mixture was treated in a similar procedure as Synthesis Example 1, there was obtained a 68.0% yield of 2-chloro-5-fluoro-4-thiocyanopyrimidine, m.p. 103°-104° C. NMR (DMSO-d₆) δ=8.85 ppm (s). IR (KBr): 2180 cm^-1 (-SCN)

References:

US4814337,1989,A