ChemicalBook CAS DataBase List 2-CHLORO-6-PHENYLPYRAZINE

2-CHLORO-6-PHENYLPYRAZINE synthesis

14synthesis methods

Product Name:2-CHLORO-6-PHENYLPYRAZINE
CAS Number:41270-62-6
Molecular formula:C10H7ClN2
Molecular Weight:190.63

4774-14-5 Synthesis

4774-14-5
327 suppliers
$5.00/1g

98-80-6 Synthesis

98-80-6
712 suppliers
$5.00/5g

41270-62-6
50 suppliers
$45.00/10mg

Yield:41270-62-6 75%

Reaction Conditions:

with sodium carbonate;dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ in 1,2-dimethoxyethane;water at 120; for 0.25 h;Microwave irradiation;Suzuki Coupling;

Steps:

Synthesis o -chloro-6-phenylpyrazine[00145] To a solution of 2,6-dichloropyrazine (2.0 equiv.) in 3 : 1 DME:2M aqueous sodium carbonate (0.125 M) was added phenylboronic acid (1.0 equiv.) then PdCl₂(dppf) · DCM adduct (0.1 equiv.). The reaction was heated in the microwave at 120 °C for 15 minutes. The crude reaction mixture was diluted with ethyl acetate and washed with sat. aq. sodium bicarbonate then sat. NaCl. The organic phase was dried with magnesium sulfate, filtered, and concentrated. The crude material was purified by silica gel column chromatography with heptanes to 30% ethyl acetate in heptanes to give 2- chloro-6-phenylpyrazine in 75% yield. LC/MS (m/z): 191.0 (MH⁺), R, = 1.00 min.

References:

WO2012/4217,2012,A1 Location in patent:Page/Page column 63

1074-12-0 Synthesis