2-Chloro-N-(2-phenylsulfanyl-phenyl)-acetamide synthesis

Yield:22504-08-1 91%

Reaction Conditions:

in toluene; for 0.166667 h;Microwave irradiation;

Steps:

5.1.1. General procedure for obtaining the N-acyl-derivatives (2, 4, 6, 7, 8, 10, 11, 15)

General procedure: To a solution of 10H-phenothiazine (2.62 mmol) in dry toluene (5 mL) was added drop by drop the corresponding acyl chloride (0.5 mL; 6.2 mmol). The reaction was irradiate with MW (500 Watts) during 10 min, then was washed with NaOH 5% (2 × 5 mL) and the organic phase was dry with anhydrous Na₂SO₄. Finally the solvent was remove in vacuo.

References:

Sarmiento, Gabriela P.;Vitale, Roxana G.;Afeltra, Javier;Moltrasio, Graciela Y.;Moglioni, Albertina G. [European Journal of Medicinal Chemistry,2011,vol. 46,# 1,p. 101 - 105] Location in patent:experimental part