![](/StructureFile/ChemBookStructure3/GIF/CB6375045.gif)
2-CHLORO-N-(4-FLUOROBENZYL)ACETAMIDE synthesis
- Product Name:2-CHLORO-N-(4-FLUOROBENZYL)ACETAMIDE
- CAS Number:257279-75-7
- Molecular formula:C9H9ClFNO
- Molecular Weight:201.63
![Chloroacetyl chloride](/CAS/GIF/79-04-9.gif)
79-04-9
351 suppliers
$12.00/5g
![4-Fluorobenzylamine](/CAS/GIF/140-75-0.gif)
140-75-0
459 suppliers
$10.00/10g
![2-CHLORO-N-(4-FLUOROBENZYL)ACETAMIDE](/StructureFile/ChemBookStructure3/GIF/CB6375045.gif)
257279-75-7
25 suppliers
$39.00/1mg
Yield:257279-75-7 88.04%
Reaction Conditions:
with triethylamine in dichloromethane at 0 - 20; for 6 h;
Steps:
1 General procedure for the synthesis of 12a-g
General procedure: 2-chloroacetyl chloride (1.5 mmol) was added dropwise to a mixture of amine (1 mmol) and triethylamine (3 mmol) in 20 mL dichloromethane originally at 0 °C with stirring. Then the resulting mixture was cooled to ambient temperature and stirred for 6 h. After removal of dichloromethane solvents on a rotary evaporator, water was added and extract with ethyl acetate (3 × 30 mL). The organic layer was combined and dried with sodium sulfate. The solution was evaporated to give the crude product, which was purified by Silica gel column chromatography with ethyl acetate-petroleum ether as eluent.
References:
Zhang, Mingming;Zhu, Weiliang;Li, Yingxia [European Journal of Medicinal Chemistry,2013,vol. 62,p. 301 - 310]
![Chloroacetic acid](/CAS/GIF/79-11-8.gif)
79-11-8
10 suppliers
$27.00/25g
![4-Fluorobenzylamine](/CAS/GIF/140-75-0.gif)
140-75-0
459 suppliers
$10.00/10g
![2-CHLORO-N-(4-FLUOROBENZYL)ACETAMIDE](/StructureFile/ChemBookStructure3/GIF/CB6375045.gif)
257279-75-7
25 suppliers
$39.00/1mg