(2-Chloroethyl)sulfaMoyl Chloride synthesis

Yield:53627-11-5 86%

Reaction Conditions:

with sulfuryl dichloride in acetonitrile at 80;

Steps:

N-(2-chloroethyl)sulfamoyl chloride

2-chloroethylamine hydrochloride (0.50 g, 4.3 mmol), sulfuryl chloride (3.49 g, 2.10 mL, 25.8 mmol), were dissolved in acetonitrile (5.0 mL) Reactionwas stirred at 80°C overnight. The mixture was concentrated and used directly into next step. Title compound was obtained as yellow oil (0.5g, 86% yield). 1H NMR (300 MHz, d6-DMSO) 6 11 .0 (bs, 1 H), 3.83 (t, 2H), 3.36 (t, 2H)

References:

WO2018/178384,2018,A1 Location in patent:Page/Page column 180