ChemicalBook CAS DataBase List 2-Chloropropionic acid

2-Chloropropionic acid synthesis

12synthesis methods

Product Name:2-Chloropropionic acid
CAS Number:598-78-7
Molecular formula:C3H5ClO2
Molecular Weight:108.52

79-33-4 Synthesis

79-33-4
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$6.00/25g

598-78-7
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$9.00/1g

Yield:-

Reaction Conditions:

Stage #1:L-Lactic acid with thionyl chloride
Stage #2:Alkaline conditions;

Steps:

3 Comparative Example 3 Refinement of Alanylglutamine (Ammonia Used as Amination Reagent)
Alanylglutamine is prepared according to CN1786019A. Wherein, esterified L-lactic acid reacts with thionyl chloride in the presence of a catalyst to give 2-chloropropionate; 2-chloropropionate is hydrolyzed with basic solution to give 2-chloropropionic acid; 2-chloropropionic acid reacts with a chlorinating reagent to give 2-chloropropionic chloride; 2-chloropropionic chloride reacts with L-glutamine to provide N-(2-chloro)-propionyl-glutamine; N-(2-chloro)-propionyl-glutamine reacts with aqueous ammonia to generate alanylglutamine crude product. However, the reaction solution contains salt impurities such as ammonium chloride, which causes difficulties in subsequent purification processes.

References:

HAINAN LINGKANG PHARMACEUTICAL CO., LTD.;Tao, Linggang US2015/38740, 2015, A1 Location in patent:Paragraph 0076

802294-64-0 Synthesis