ChemicalBook CAS DataBase List 2-chloroquinolin-8-ol

2-chloroquinolin-8-ol synthesis

6synthesis methods

Product Name:2-chloroquinolin-8-ol
CAS Number:31568-91-9
Molecular formula:C9H6ClNO
Molecular Weight:179.6

15450-76-7 Synthesis

15450-76-7
294 suppliers
$6.00/1g

31568-91-9
62 suppliers
$57.50/250 mg

Yield:31568-91-9 77%

Reaction Conditions:

with thionyl chloride;N,N-dimethyl-formamide at 20 - 50; for 5.5 h;Cooling with ice;

Steps:

1 Synthesis of 50
Synthesis of 50
To a N,N-dimethylformamide (20 ml) suspension of 1 (2.00 g, 12.4 mmol), thionyl chloride (3.56 ml, 49.6 mmol) was added dropwise under ice cooling and stirring, and the mixture was stirred at room temperature for 2 hours, and then thionyl chloride (3.56 ml, 49.6 mmol) was added, followed by further stirring at 50°C for 3.5 hours. The reaction solution was allowed to return to room temperature, poured into ice water and extracted with ethyl acetate. The extraction liquid was washed with water and dried, and then the solvent was distilled off under reduced pressure. The residue was purified by silica gel column chromatography (eluting solvent: ethyl acetate/n-hexane = 1/20) to obtain 50 (1.72 g, 77%) as a pale yellow solid. mp 79-80°C, APCI-MS m/z 180/182[M+H]⁺

References:

Clino Ltd.;KUDO, Yukitsuka;FURUMOTO, Syozo;OKAMURA, Nobuyuki EP2634177, 2013, A1 Location in patent:Paragraph 0217; 0218

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1127-45-3 Synthesis