2-cyano-N-(pyridin-4-ylmethyl)acetamide synthesis
- Product Name:2-cyano-N-(pyridin-4-ylmethyl)acetamide
- CAS Number:15029-28-4
- Molecular formula:C9H9N3O
- Molecular Weight:175.19
Yield:15029-28-4 87.7%
Reaction Conditions:
in neat (no solvent) at 20; for 4 h;
Steps:
General Procedure for the Synthesis of thePicolylcyanoacetamides
General procedure: The relevant picolylamine was slowly added to stirred neat methyl cyanoacetate (mca). The reaction mixture was stirred at room temperature for 4 h during which time a precipitate formed. The precipitate was recovered by filtration, washed several times with diethyl ether, and finally dried with N2 to yield the pure compound as a white powder.
References:
Prananto, Yuniar P.;Urbatsch, Aron;Moubaraki, Boujemaa;Murray, Keith S.;Turner, David R.;Deacon, Glen B.;Batten, Stuart R. [Australian Journal of Chemistry,2017,vol. 70,# 5,p. 516 - 528]
