(2-Cyclopentylthiazol-5-yl)methanol synthesis

4synthesis methods

Product Name:(2-Cyclopentylthiazol-5-yl)methanol
CAS Number:1494277-04-1
Molecular formula:C9H13NOS
Molecular Weight:183.2706

Ethyl 2-cyclopentylthiazole-5-carboxylate

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Yield:1494277-04-1 87%

Reaction Conditions:

with lithium aluminium tetrahydride in tetrahydrofuran at 0 - 30; for 3 h;

Steps:

16.4 Step 4

To a mixture of 25d (3 g, 13.3 mmol) in THF (50 mL) was added LiAlH₄ (760 mg 20mmol) in portions with stirring at 0 °C and then stirred at 30°C for 3 hours. The mixture was quenched with water. After filtration and concentration in vacuo, and the resutling residue was purified using Si0₂ chromatography, eluting with petroleum ether: ethyl acetate (100/1-10/1) to provide 25e (2.1 g, 87%). 1H- NMR (CDC1₃) δ: 7.43 (s, 1H), 4.78 (s, 2H), 3.37 (q, J=7.8 Hz, 1H), 2.20 - 2.10 (m, 2H), 1.79 (d, J=3.5 Hz, 4H), 1.66 (d, J=3.5 Hz, 2H)

References:

WO2014/110705,2014,A1 Location in patent:Page/Page column 85

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References

3217-94-5
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References

42202-73-3 Synthesis

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References