ChemicalBook CAS DataBase List 2-[(E)-2-Carboxyethenyl]benzoic acid

2-[(E)-2-Carboxyethenyl]benzoic acid synthesis

13synthesis methods

Product Name:2-[(E)-2-Carboxyethenyl]benzoic acid
CAS Number:18454-53-0
Molecular formula:C10H8O4
Molecular Weight:192.17

91-20-3 Synthesis

91-20-3
491 suppliers
$14.00/25g

18454-53-0
6 suppliers
inquiry

130-15-4 Synthesis

130-15-4
399 suppliers
$16.00/1g

Yield:18454-53-0 56% ，130-15-4 34%

Reaction Conditions:

with Oxone in water;acetonitrile; for 36 h;Reflux;

Steps:

6.2 General procedure for oxidation of benzyl halides, alcohols, and aromatic hydrocarbons

General procedure: To 16 mL of acetonitrile/water (1:1 v/v) mixture was added 0.5-1.2 mmol of the starting compound. The contents were heated at reflux with introduction of oxone (cf. entries for each case) incrementally over the entire duration of the reaction. For secondary benzyl halides, the reactions were run at room temperature. The progress of the reaction in each case was monitored by TLC analysis. After completion of the reaction, the reaction mixture was cooled to room temperature and the organic matter was extracted with ethyl acetate. The combined organic extract was dried over anhyd Na₂SO₄ and concentrated in vacuo. Short pad silica gel column chromatography of the residue led to isolation of the pure product.

References:

Parida, Keshaba Nanda;Jhulki, Samik;Mandal, Susovan;Moorthy, Jarugu Narasimha [Tetrahedron,2012,vol. 68,# 47,p. 9763 - 9768,6]

135-19-3 Synthesis