2-Ethoxybenzoyl chloride synthesis

Yield:42926-52-3 99.7%

Reaction Conditions:

with phosgene;N,N-dimethyl-formamide in acetone at 50;

Steps:

1.3-8.3 (3) Acrylic chlorination reaction:
15.8g product b o-ethoxybenzoic acid obtained in step (2) is completely dissolved in acetone, and placed in a three-necked flask equipped with a reflux condenser, and a small amount of 0.07mL DMF is used as a promoter, 31.0g solid phosgene is added, 34.5mg supported ytterbium perfluorooctane sulfonate [Yb(OPf)3] is used as a catalyst, and the reaction is carried out at 50, followed by TLC tracking until the raw material point disappears; After the completion, the mixture was allowed to stand at room temperature for 30 minutes, and then filtered to obtain a filter cake and filtrate.The filtrate was concentrated and processed by high performance liquid chromatography to obtain 17.5 g of the target product o-ethoxybenzoyl chloride with a purity of 98%.The yield was 99.7%.

References:

Jiangsu Julai Bio-pharmaceutical Co., Ltd.;Wang Jun;Wang Ting CN111548263, 2020, A Location in patent:Page/Page column 5-10

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