![](/CAS/GIF/42926-52-3.gif)
2-Ethoxybenzoyl chloride synthesis
- Product Name:2-Ethoxybenzoyl chloride
- CAS Number:42926-52-3
- Molecular formula:C9H9ClO2
- Molecular Weight:184.62
![2-Ethoxybenzoic acid](/CAS/GIF/134-11-2.gif)
134-11-2
376 suppliers
$6.00/5g
![2-Ethoxybenzoyl chloride](/CAS/GIF/42926-52-3.gif)
42926-52-3
277 suppliers
$9.00/5g
Yield:42926-52-3 99.7%
Reaction Conditions:
with phosgene;N,N-dimethyl-formamide in acetone at 50;
Steps:
1.3-8.3 (3) Acrylic chlorination reaction:
15.8g product b o-ethoxybenzoic acid obtained in step (2) is completely dissolved in acetone, and placed in a three-necked flask equipped with a reflux condenser, and a small amount of 0.07mL DMF is used as a promoter, 31.0g solid phosgene is added, 34.5mg supported ytterbium perfluorooctane sulfonate [Yb(OPf)3] is used as a catalyst, and the reaction is carried out at 50, followed by TLC tracking until the raw material point disappears; After the completion, the mixture was allowed to stand at room temperature for 30 minutes, and then filtered to obtain a filter cake and filtrate.The filtrate was concentrated and processed by high performance liquid chromatography to obtain 17.5 g of the target product o-ethoxybenzoyl chloride with a purity of 98%.The yield was 99.7%.
References:
Jiangsu Julai Bio-pharmaceutical Co., Ltd.;Wang Jun;Wang Ting CN111548263, 2020, A Location in patent:Page/Page column 5-10
![Methyl salicylate](/CAS/GIF/119-36-8.gif)
119-36-8
991 suppliers
$5.00/10g
![2-Ethoxybenzoyl chloride](/CAS/GIF/42926-52-3.gif)
42926-52-3
277 suppliers
$9.00/5g