ChemicalBook CAS DataBase List 2-FLUORO-4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID

2-FLUORO-4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID synthesis

5synthesis methods

Product Name:2-FLUORO-4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID
CAS Number:503309-11-3
Molecular formula:C7H5BF4O2
Molecular Weight:207.92

5419-55-6
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$12.00/5g

401-80-9 Synthesis

401-80-9
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$5.00/10g

2-FLUORO-4-(TRIFLUOROMETHYL)PHENYLBORONIC ACID

503309-11-3
211 suppliers
$15.00/1g

Yield:503309-11-3 86%

Reaction Conditions:

Stage #1: Triisopropyl borate;3-fluoro-trifluoromethylbenzenewith lithium diisopropyl amide in tetrahydrofuran at -70 - 30; for 1.5 h;
Stage #2: with hydrogenchloride in water; pH=2 - 3;Temperature;Time;Reagent/catalyst;

Steps:

1-20; 23-31 Example 1

Put 20g (1.0equiv.) m-fluorobenzotrifluoride,Triisopropyl borate (2.1eq) was dissolved in 400mL tetrahydrofuran to obtain a dispersion,Use a dry ice ethanol bath to cool the above dispersion to -70°C,Add 1.9eq LDA dropwise to the dispersion,After the incubation reaction for 1h,Slowly return to room temperature (heating rate is 2°C/min),Heat the system to 30°C in an oil bath, keep it warm and react for 30min,Add 200 mL of water to the system to quench the reaction,After stirring at 250r/min for 30min,Reduce pressure to -0.1MPa and concentrate to remove tetrahydrofuran,Then add concentrated hydrochloric acid with a concentration of 12N to adjust the pH to 2~3, separate out the solid and filter with suction.Obtain 2-fluoro-4-trifluoromethylphenylboronic acid,The purity of the product is 99.6%, and the yield is 86%.

References:

CN112979688,2021,A Location in patent:Paragraph 0051-0070; 0073-0081