ChemicalBook CAS DataBase List 2-Fluoro-5-Methanesulfonylbenzoic acid

2-Fluoro-5-Methanesulfonylbenzoic acid synthesis

7synthesis methods

Product Name:2-Fluoro-5-Methanesulfonylbenzoic acid
CAS Number:247569-56-8
Molecular formula:C8H7FO4S
Molecular Weight:218.2

57318-98-6 Synthesis

57318-98-6
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247569-56-8
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Yield:247569-56-8 79%

Reaction Conditions:

with potassium peroxymonosulfate in methanol at 0 - 20; for 72 h;

Steps:

3.b

To 2.68 mmol 2-fluoro-5-methanesulfanyl-benzoic acid in 5 ml methanol at 0° C. was added 8.05 mmol Oxone and the mixture was allowed to stir at RT for 72 h. The precipitate was filtered off and the filtrate was concentrated under reduced pressure. The residue was treated with water and extracted 3 times with 400 ml dichloromethane. The combined organic phases were dried over sodium sulfate. Evaporation under reduced pressure yielded the title compound as a white crystalline solid (yield 79%). MS (m/e): 217.2 (M-H⁺, 100%).

References:

US2006/149062,2006,A1 Location in patent:Page/Page column 9-10