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ChemicalBook CAS DataBase List 2-FLUORO-6-PYRIDINECARBONYL CHLORIDE
64197-03-1

2-FLUORO-6-PYRIDINECARBONYL CHLORIDE synthesis

4synthesis methods
-

Yield:64197-03-1 97%

Reaction Conditions:

N,N-dimethyl-formamide in dichloromethane at 20; for 24 h;

Steps:



Oxalyl chloride (1.35 g, 10.6 mmol) was added to a stirred solution of 6-fluoropicolinic acid (1.0 g, 7.09 mmol) in CH2Cl2 (25 mL) at rt under argon atmosphere. A drop of DMF was added to initiate reaction. After stirring for 24 h at rt, the solvents were removed in vacuo to yield the acid chloride as a colorless solid (1.35 g, 97%).

References:

US2007/213376,2007,A1 Location in patent:Page/Page column 13

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