ChemicalBook CAS DataBase List 2-Fluoroanisole

2-Fluoroanisole synthesis

7synthesis methods

Product Name:2-Fluoroanisole
CAS Number:321-28-8
Molecular formula:C7H7FO
Molecular Weight:126.13

367-12-4 Synthesis

367-12-4
422 suppliers
$5.00/10g

74-88-4
348 suppliers
$15.00/10g

321-28-8
367 suppliers
$6.00/1g

Yield:321-28-8 98%

Reaction Conditions:

Stage #1:2-fluorophenol with sodium hydride in N,N-dimethyl-formamide at 0 - 20; for 1.5 h;
Stage #2:methyl iodide in N,N-dimethyl-formamide for 16 h;

Steps:

D.D1
D 1. 1 -Fluoro-2-methoxy-benzeneTo a slurry of NaH (28.8g, O.όOmol) in dry DMF (500ml) at 0 ⁰C was added 2-fluoro phenol (5Og, 0.446mol) slowly over a period of 30min and stirred for Ih at room EPO temperature. To this was added methyl iodide (19Og, 1.33mol) and the reaction mixture was stirred for 16h under nitrogen and poured into ice-water (1.5L). The product was extracted with ethyl acetate (2 x 200ml), washed with water, brine and dried. The solvent was removed under vacuum to afford 55g (98%) of the title compound.

References:

ASTEX THERAPEUTICS LIMITED;THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL;ASTRAZENECA AB WO2006/136829, 2006, A2 Location in patent:Page/Page column 122-123

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367-12-4 Synthesis

367-12-4
422 suppliers
$5.00/10g

77-78-1
298 suppliers
$19.69/1ml

321-28-8
367 suppliers
$6.00/1g

References

90-05-1 Synthesis

90-05-1
743 suppliers
$5.00/1g

321-28-8
367 suppliers
$6.00/1g

References

100-66-3 Synthesis

100-66-3
514 suppliers
$10.00/5G

459-60-9 Synthesis

459-60-9
353 suppliers
$7.00/5g

321-28-8
367 suppliers
$6.00/1g

References

578-57-4
299 suppliers
$6.00/10g

321-28-8
367 suppliers
$6.00/1g

100-66-3 Synthesis

100-66-3
514 suppliers
$10.00/5G

References

2-Fluoroanisole Related Search:

Florfenicol Transfluthrin Anisole 4-Fluorobenzaldehyde 2-Fluorobenzaldehyde 2-Fluorobenzoyl chloride 2-Fluorobenzoic acid 2-Fluorophenylacetic acid alpha-Chloro-o-fluorotoluene 4-Fluoroanisole