2-Formylpyridine thiosemicarbazone synthesis
- Product Name:2-Formylpyridine thiosemicarbazone
- CAS Number:3608-75-1
- Molecular formula:
- Molecular Weight:0
Yield:3608-75-1 87%
Reaction Conditions:
with hydrogenchloride in ethanol;water at 100; for 5 h;
Steps:
2.2.2. Pyridine 2-carbaldehyde thiosemicarbazone (HL2)
The chemical scheme of HL2 [15, 16] is shown in scheme 2. For synthesis of HL2, hot ethanolic solution of thiosemicarbazide (0.8 g, 7 mM) and ethanolic solution of pyridine-2-carbaldehyde (0.85 mL, 7 mM)were mixed in the presence of a few drops of concentrated HCl with constant stirring. This mixture was refluxed at 100 °C for 5 h. The reaction mass on cooling gave cream-colored crystals, which were filtered off, washed with ethanol, and dried in air (yield: 1.40 g (87 %), m.p. 185 °C). Anal. Calcd for C7H8N4S: C, 30.01; H, 2.85; N, 20.01. Found: C, 30.23; H,2.98; N, 20.32. Characteristic IR absorptions (cm-1): 3424m, ν(NH2); 3185m, ν(NH); 1604s, ν(C=N); 1112s, ν(N-N); 844s, 1246s, ν(C=S).
References:
Shaabani, Behrouz;Khandar, Ali Akbar;Dusek, Michal;Pojarova, Michaela;Maestro, Miguel Anxo;Mukherjee, Rabindranath;Mahmoudi, Farzaneh [Journal of Coordination Chemistry,2014,vol. 67,# 12,p. 2096 - 2109]
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