ChemicalBook CAS DataBase List 2-Indanone

2-Indanone synthesis

10synthesis methods

Product Name:2-Indanone
CAS Number:615-13-4
Molecular formula:C9H8O
Molecular Weight:132.16

2-Indanone is prepared by using acetic acid as solvent, acetic anhydride as catalyst and through hydrogen peroxide oxidation into 1, 2-indenediol, which reacted with dilute sulfuric acid solution in order to obtain crude 2-indanone. Finally, vacuum sublimation to obtain 2-indanone with high-purity, the total yield is 89%.

95-13-6
296 suppliers
$6.00/25g

615-13-4
406 suppliers
$8.00/5g

Yield:615-13-4 97.1%

Reaction Conditions:

Stage #1: 1-indenewith dihydrogen peroxide;acetic anhydride;acetic acid at 40 - 55; for 14 h;Green chemistry;
Stage #2: with sulfuric acid in water monomer at 5 - 50; for 3 h;Green chemistry;

Steps:

1-10 A method for synthesizing an intermediate 2-indanone, characterized in that the method comprises the following steps:

Step 1. Add 45 ml of glacial acetic acid, 27 ml of hydrogen peroxide and 3 g of AlCl3/SBA-15 supported catalyst to a 250 ml three-necked flask, and stir at 50 ° C;Step 2, was slowly added dropwise under incubation conditions 120ml 30ml of acetic anhydride and indene,Keep the reaction temperature not exceeding 55 ° C, complete the dropwise addition within 2 h, and react at 40 ° C for 12 h;Step 3, the solvent and water after the reaction are distilled off under reduced pressure, and the remaining liquid is cooled to -15 ° C for 2 h, the precipitated product is suction filtered, washed twice with distilled water, and dried under vacuum at 60 ° C for 8 h to obtain a white preliminary product;Step 4, take 10gThe initial product is added toIn a 250 ml round bottom flask,Add 50 ml of 10% dilute sulfuric acid aqueous solution, stir at 50 ° C for 2 h, cool to 5 ° C for 1 h, and filter to obtain pale yellow 2-indanone crude product;Step 5. The 2-indanone crude product is added to a 100 ml micro-sublimation apparatus, heated at 50 ° C, and the oil pump is sublimed under reduced pressure to obtain a white crystal 2-indanone.

References:

CN109232211,2019,A Location in patent:Paragraph 0008-0029