ChemicalBook CAS DataBase List 5-Bromo-1-indanone

5-Bromo-1-indanone synthesis

11synthesis methods

Product Name:5-Bromo-1-indanone
CAS Number:34598-49-7
Molecular formula:C9H7BrO
Molecular Weight:211.06

5-Bromoindanone can be used as organic synthesis intermediate and pharmaceutical intermediate in laboratory research and development process and chemical production process. And 5-Bromoindanone can be synthesized by Friedel-Crafts reaction of 3-(3-Bromophenyl)propionic acid with chlorosulfonic acid.

34598-50-0 Synthesis

34598-50-0
61 suppliers
$66.00/100mg

34598-49-7
377 suppliers
$14.00/5g

Yield:34598-49-7 92%

Reaction Conditions:

with tert.-butylhydroperoxide in water at 100; for 24 h;

Steps:

General procedure for the oxidative reaction
General procedure: Caution. tert-Butyl hydroperoxide is an exceptionally dangerous chemical that is highly reactive, flammable, and toxic. It is corrosive to skin and mucous membranes and causes respiratory distress when inhaled. A solution of secondary alcohol (1 mmol) and 70% TBHP (6 or 10 equiv.) was stirred at 100 °C for 24 h. The reaction mixture was quenched with the saturated solution of sodium thiosulfate (5 mL) and extracted with dichloromethane (3 x 10 mL). The combined dichloromethane extracts were dried over anhydrous Na₂SO₄ and filtered, and then the solvent was removed under reduced pressure. The residue was purified by flash column chromatography on silica gel with PE or PE/EtOAc as the eluent to obtain the desired products.

References:

Wu, Jianglong;Liu, Yan;Ma, Xiaowei;Liu, Ping;Gu, Chengzhi;Dai, Bin [Synthetic Communications,2016,vol. 46,# 21,p. 1747 - 1758] Location in patent:supporting information

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31736-73-9 Synthesis