Pinaverium bromide synthesis
- Product Name:Pinaverium bromide
- CAS Number:53251-94-8
- Molecular formula:C26H41Br2NO4
- Molecular Weight:591.42
53207-00-4
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![(1S,2S,5S)-4-[2-[2-(6,6-DiMethylbicyclo[3.1.1]hept-2-yl)ethoxy]ethyl]Morpholine](/CAS/20150408/GIF/38284-47-8.gif)
38284-47-8
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53251-94-8
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Yield:53251-94-8 92.1%
Reaction Conditions:
in butanoneReflux;Solvent;
Steps:
7-9
6g of compound of formula IV and 8.5g2-bromo-4,5-dimethoxybenzyl bromide was dissolved in 60 mL of methyl ethyl ketone and heated to reflux. The reaction was completely detected by TCL, filtered, washed with methyl ethyl ketone and dried under reduced pressure to obtain 11.6 g of pivavironium bromide. The yield was 92.1%. The cis isomer is ≥99% and the trans isomer is ≤1%.
References:
Beijing Wansheng Pharmaceutical Co., Ltd.;Cheng Dan;Lin Guoliang;Geng Yuxian;Wang Qiang;Liu Zhidong;Jiang Yugang;Hu Kaixin;Zhou Haohui CN104650005, 2018, B Location in patent:Paragraph 0076; 0080; 0081; 0084; 0085; 0088
1440-61-5
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$10.00/1g
53251-94-8
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$35.00/5mg
128-50-7
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53251-94-8
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![2-(6,6-dimethylbicyclo[3.1.1]hept-2-yl)ethanol](/CAS/GIF/4747-61-9.gif)
4747-61-9
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53251-94-8
168 suppliers
$35.00/5mg