ChemicalBook CAS DataBase List 2-Methoxy-1-(4'-trifluoromethyl)phenylethanone

2-Methoxy-1-(4'-trifluoromethyl)phenylethanone synthesis

9synthesis methods

Product Name:2-Methoxy-1-(4'-trifluoromethyl)phenylethanone
CAS Number:26771-69-7
Molecular formula:C10H9F3O2
Molecular Weight:218.17

383-53-9 Synthesis

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865-33-8
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2-Methoxy-1-(4'-trifluoromethyl)phenylethanone

26771-69-7
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Yield:26771-69-7 > 95 %Chromat.

Reaction Conditions:

in methanol at 20; for 24 h;

Steps:

2 COMPARATIVE EXAMPLE 2

COMPARATIVE EXAMPLE 2 [A PRESSURE-PROOF GLASS VESSEL WAS CHARGED WITH L. 00G (3. 74MMOL, LEQ. )] [OF 2-BROMO-4'-TRIFLUOROMETHYLACETOPHENONE] and 4. 38g of 30% [MEOK] solution containing 18. [74MMOL] (5. [01EQ.)] of [MEOK] dissolved in methanol, followed by stirring for 24hr at room temperature. After the reaction, the reaction liquid was poured into a saturated brine, followed by extraction with ethyl acetate. The collected organic layer was dried with anhydrous sodium sulfate, followed by filtration, concentration and vacuum drying, thereby obtaining 0.94g of a crude product [OF A TRIFLUOROMETHYL-SUBSTITUTED 2-ALKOXYACETOPHENONE] derivative represented by the following formula. As a result of an analysis of the crude product with gas chromatography and [1H-NMR] and 19F-NMR, it was found that the raw material had almost been consumed (conversion>95%). However, the yield was found by a 19F-NMR internal standard method to be less than 5%.

References:

WO2004/14887,2004,A1 Location in patent:Page 27-28