ChemicalBook CAS DataBase List 2-methoxy-1,7,9-trimethylpurine-6,8-dione

2-methoxy-1,7,9-trimethylpurine-6,8-dione synthesis

9synthesis methods

Product Name:2-methoxy-1,7,9-trimethylpurine-6,8-dione
CAS Number:51168-26-4
Molecular formula:C9H12N4O3
Molecular Weight:224.22

1H-Purine-6,8-dione, 7,9-dihydro-2-methoxy-1,7-dimethyl-

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2-methoxy-1,7,9-trimethylpurine-6,8-dione

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Yield:51168-26-4 90%

Reaction Conditions:

with potassium tert-butylate in acetonitrile at 20 - 90; for 12 h;

Steps:

11.2

The cyclate obtained in the previous step (9.11 g, 43 mmol) was suspended in acetonitrile, and potassium t-butoxide (52 mmol) was added. Methyl iodide (52 mmol) was added at 20-30 °C. The reaction was carried out at 80-90 ° C for 12 hours, and the basic reaction of the raw materials was completed. Concentrate and beat with water and methanol in sequence. After drying, 8.7 g of white tetramethyl uric acid was obtained in a yield of 90%. The purity is 98%.

References:

CN108912121,2018,A Location in patent:Paragraph 0148; 0153; 0154; 0156