2'-METHOXY-P-TOLUENESULFONANILIDE synthesis
- Product Name:2'-METHOXY-P-TOLUENESULFONANILIDE
- CAS Number:6295-94-9
- Molecular formula:C14H15NO3S
- Molecular Weight:277.34
Yield:6295-94-9 94%
Reaction Conditions:
Stage #1: toluene-4-sulfonic acid hydrazidewith N-chloro-succinimide in acetonitrile at 20; for 2 h;
Stage #2: 2-methoxy-phenylaminewith triethylamine at 20; for 2 h;
Steps:
4.4. General Procedure for One-Port Reaction with Nucleophile
General procedure: N-Chlorosuccinimide 2a (0.6 mmol, 2.0 equiv) was added to a solution of 4-methylbenzenesulfonhydrazide 1a (0.3 mmol) in CH3CN (2 mL) in one portion. Themixture was stirred at room temperature for 2 h. Then, Et3N (0.6 mmol, 2.0 equiv) andnucleophile (0.6 mmol, 2.0 equiv) were added to the above reaction system, and the mixturewas stirred at room temperature for 2 h. The solvent was removed, and the residuewas purified by flash column chromatography (PE/EA) to provide the correspondingsulfonamides and sulfonate 7.
References:
Chen, Rongxiang;Xu, Shaohong;Shen, Fumin;Xu, Canran;Wang, Kaikai;Wang, Zhanyong;Liu, Lantao [Molecules,2021,vol. 26,# 18,art. no. 5551]
