2-Methyl-3-phenyl-furo[3,2-c]chromen-4-one synthesis
- Product Name:2-Methyl-3-phenyl-furo[3,2-c]chromen-4-one
- CAS Number:10375-42-5
- Molecular formula:C18H12O3
- Molecular Weight:276.29
Yield:10375-42-5 76%
Reaction Conditions:
with copper(II) bis(trifluoromethanesulfonate) in monoethylene glycol diethyl ether at 80; for 2 h;
Steps:
1 Example 1 Preparation of 2-methyl-3-phenyl -4H-furo[3.2-c]coumarin (2-methyl-3-phenyl-4 H-furo [3.2-c] coumarin)
Test tube in dichloroethane (1.5 mL), the solvent in the trifluoromethane sulfonate copper (II) salt((Cu(OTf) 2),5.43 mg, 0.015 mmol) existing under 4-hydroxy coumarin (58.37 mg , a 0.36 mmol) and 1-phenyl-2-propyn-1-ol (39.65 mg, 0.3 mmol) were mixed and then stirred at 80 .After the reaction was completed after 2 hours by using water to remove the catalyst, and extracted with dichloromethane.After removal of the solvent and purified by column chromatography to separate the title compound by in the formula (4) 2-methyl-3-phenyl-4H- furo [3.2-c] coumarin were obtained (63 mg, 76%).The by-product of furo [2.3-b] was not driven Croix compounds are created.
References:
KR101504189,2015,B1 Location in patent:Paragraph 0072-0074
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