ChemicalBook CAS DataBase List 2-Methyl-3-trifluoromethylaniline

2-Methyl-3-trifluoromethylaniline synthesis

8synthesis methods

Product Name:2-Methyl-3-trifluoromethylaniline
CAS Number:54396-44-0
Molecular formula:C8H8F3N
Molecular Weight:175.15

150783-50-9 Synthesis

2,2-DIMETHYL-N-[2-METHYL-3-(TRIFLUOROMETHYL)PHENYL]-PROPIONAMIDE

150783-50-9
20 suppliers
$130.00/100mg

54396-44-0
355 suppliers
$10.00/5g

Yield:54396-44-0 98.5%

Reaction Conditions:

with hydrogenchloride in ethanol;

Steps:

Preparation of 2-Methyl-3-Trifluoromethyl-Aniline

Preparation of 2-Methyl-3-Trifluoromethyl-Aniline A solution of 2,2,2'-trimethyl-3'-trifluoromethyl-propionanilide (10 g.) in 75 ml. ethanol and 75 ml. concentrated HCl was refluxed for 24 hours. The reaction mixture was then concentrated in vacuo and diluted with water. It was then basified with 10% NaOH solution and extracted with ether. The ether extract was washed with water and brine and dried with MgSO₄. Removal of ether gave a pale brown liquid (6.65 g., 98.5%) which was purified by distillation under reduced pressure (b.p. 108°-110° C., 30 mm.) to give 5.73 g. of 2-methyl-3-trifluoromethyl-aniline which solidified on standing. The physical and spectroscopic properties of the product were found to be identical to those of an authentic sample of 2-methyl-3-trifluoromethyl-aniline prepared by the known method below. STR2

References:

US5248781,1993,A