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2-Methyl-4-((triMethylsilyl)ethynyl)thiazole synthesis

4synthesis methods
18245-82-4 Synthesis
1-CHLORO-4-TRIMETHYLSILANYL-BUT-3-YN-2-ONE

18245-82-4
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2-Methyl-4-((triMethylsilyl)ethynyl)thiazole

329203-85-2
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Yield:329203-85-2 72%

Reaction Conditions:

in N,N-dimethyl-formamide at 20; for 16 h;

References:

Cosford, Nicholas D. P.;Tehrani, Lida;Roppe, Jeffrey;Schweiger, Edwin;Smith, Nicholas D.;Anderson, Jeffrey;Bristow, Linda;Brodkin, Jesse;Jiang, Xiaohui;McDonald, Ian;Rao, Sara;Washburn, Mark;Varney, Mark A. [Journal of Medicinal Chemistry,2003,vol. 46,# 2,p. 204 - 206]