2-Methyl-5-cyanothiazole synthesis
- Product Name:2-Methyl-5-cyanothiazole
- CAS Number:65735-10-6
- Molecular formula:C5H4N2S
- Molecular Weight:124.1637
Yield:65735-10-6 66%
Reaction Conditions:
with pyridine at 50; for 3 h;
Steps:
12.3 Step 3: 2-methylthiazole-5-carbonitrile
To a 100 mL round bottom flask was added 2-methyl-l,3-thiazole-5-carboxamide (4.00 g, 28.1 mmol), tosyl chloride (13.4 mg, 70.3 mmol), and pyridine (20 mL). The reaction mixture was stirred at 50 °C for 3 h. The reaction mixture was diluted with EtOAc, washed with ~1 M HC1 (aq), water, sat. NaHCCb (aq), then brine. The organic layer was dried over MgSCri, then concentrated to afford the title compound as a brown solid (2.30 g, 66%).
References:
WO2021/127643,2021,A1 Location in patent:Paragraph 00537; 00542-00543
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