2-methylbenzofuro[2,3-b]pyridin-8-ol synthesis

9synthesis methods

Product Name:2-methylbenzofuro[2,3-b]pyridin-8-ol
CAS Number:1609373-97-8
Molecular formula:C12H9NO2
Molecular Weight:199.21

1609373-96-7 Synthesis

8-methoxy-2-methylbenzofuro[2,3-b]pyridine

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Yield:1609373-97-8 95%

Reaction Conditions:

with pyridine hydrochloride at 200; for 15 h;

Steps:

Preparation of 2-methylbenzofuro[2,3-b]pyridin-8-ol:

A mixture of 8-methoxy-2-methylbenzofuro[2,3-b]pyridine (7.6 g, 35.6 mmol) and pyridine hydrochloride (25 g,216 mmol) was heated at 200 °C for 15 h. After cooling to room temperature, the solid was sonicated with aquous sodium bicarbonate solution. The solid was isolated by filtration to yield 6.72 g (95%) of desired product as a brown powder.

References:

EP2730583,2014,A1 Location in patent:Paragraph 0153; 0154

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References

2-Pyridinamine, 3-(2,3-dimethoxyphenyl)-6-methyl-

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126325-46-0
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