![](/CAS/GIF/51012-65-8.gif)
2'-METHYLPHENACYL BROMIDE synthesis
- Product Name:2'-METHYLPHENACYL BROMIDE
- CAS Number:51012-65-8
- Molecular formula:C9H9BrO
- Molecular Weight:213.07
![o-Toluoyl chloride](/CAS/GIF/933-88-0.gif)
933-88-0
334 suppliers
$10.00/1g
![(TRIMETHYLSILYL)DIAZOMETHANE](/CAS/GIF/18107-18-1.gif)
18107-18-1
204 suppliers
$33.00/5g
![2'-METHYLPHENACYL BROMIDE](/CAS/GIF/51012-65-8.gif)
51012-65-8
112 suppliers
$26.00/200mg
Yield: 91%
Reaction Conditions:
with hydrogen bromide in hexane;water;ethyl acetate;acetonitrile
Steps:
6 Preparation of 2-bromo-1-o-tolylethanone (I15)
Example 6 Preparation of 2-bromo-1-o-tolylethanone (I15) To a solution of 2-methylbenzoyl chloride (169 μl, 1.29 mmol) in dry acetonitrile (5 ml) and cooled at 0° C., under nitrogen atmosphere, was added (diazomethyl)-trimethylsilane (1.94 ml, 3.88 mmol, 2M in hexane). The reaction was stirred at room temperature for 15 hours, then it was cooled at 0° C. and 48% HBr (512 μl, 4.53 mmol) was slowly added. The reaction was stirred at room temperature for 3 hours. EtOAc and water were added, the organic layer was separated and the aqueous phase was neutralized with 1M NaOH and extracted with EtOAc. The combined organic layers were dried over Na2SO4, filtered and evaporated to dryness to obtain 2-bromo-1-o-tolylethanone (250 mg, 91% yield). This intermediate was used in the next step without any further purification. 1H NMR (300 MHz, DMSO-d6) δ ppm 7.82-7.91 (m, 1H), 7.45-7.52 (m, 1H), 7.25-7.40 (m, 2H), 4.86 (s, 2H), 2.41 (s, 3H).
References:
Chiesi Farmaceutici S.p.A. US2011/311458, 2011, A1
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611-15-4
114 suppliers
$128.00/5g
![2'-METHYLPHENACYL BROMIDE](/CAS/GIF/51012-65-8.gif)
51012-65-8
112 suppliers
$26.00/200mg
![o-Toluoyl chloride](/CAS/GIF/933-88-0.gif)
933-88-0
334 suppliers
$10.00/1g
![2'-METHYLPHENACYL BROMIDE](/CAS/GIF/51012-65-8.gif)
51012-65-8
112 suppliers
$26.00/200mg
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238 suppliers
$40.00/100 g
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7446-70-0
685 suppliers
$15.00/25g
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$14.00/5g
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75-36-5
561 suppliers
$17.92/100G
![2'-METHYLPHENACYL BROMIDE](/CAS/GIF/51012-65-8.gif)
51012-65-8
112 suppliers
$26.00/200mg
![Carbon disulfide](/CAS/GIF/75-15-0.gif)
75-15-0
238 suppliers
$40.00/100 g
![Aluminum chloride](/CAS/GIF/7446-70-0.gif)
7446-70-0
685 suppliers
$15.00/25g
![2-Bromotoluene](/CAS/GIF/95-46-5.gif)
95-46-5
293 suppliers
$10.00/10 g
![Acetyl chloride](/CAS/GIF/75-36-5.gif)
75-36-5
561 suppliers
$17.92/100G
![2'-METHYLPHENACYL BROMIDE](/CAS/GIF/51012-65-8.gif)
51012-65-8
112 suppliers
$26.00/200mg