![](/CAS/GIF/141983-61-1.gif)
2-(NAPHTHALEN-5-YL)PROPAN-2-AMINE synthesis
- Product Name:2-(NAPHTHALEN-5-YL)PROPAN-2-AMINE
- CAS Number:141983-61-1
- Molecular formula:C13H15N
- Molecular Weight:185.26
![Methyllithium](/CAS/GIF/917-54-4.gif)
917-54-4
174 suppliers
$52.10/25ml
![1-Cyanonaphthalene](/CAS/GIF/86-53-3.gif)
86-53-3
184 suppliers
$17.85/5g
![2-(NAPHTHALEN-5-YL)PROPAN-2-AMINE](/CAS/GIF/141983-61-1.gif)
141983-61-1
13 suppliers
$549.00/500mg
Yield:141983-61-1 61%
Reaction Conditions:
Stage #1: methyllithiumwith cerium(III) chloride in tetrahydrofuran at -78 - -50;Inert atmosphere;
Stage #2: 1-Cyanonaphthalene in tetrahydrofuran at 23; for 2 h;Inert atmosphere;
Stage #3: with ammonium hydroxide in tetrahydrofuran at -78 - 23;
References:
Ghosh, Arun K.;Takayama, Jun;Aubin, Yoann;Ratia, Kiira;Chaudhuri, Rima;Baez, Yahira;Sleeman, Katrina;Coughlin, Melissa;Nichols, Daniel B.;Mulhearn, Debbie C.;Prabhakar, Bellur S.;Baker, Susan C.;Johnson, Michael E.;Mesecar, Andrew D. [Journal of Medicinal Chemistry,2009,vol. 52,# 16,p. 5228 - 5240] Location in patent:experimental part
![Methyllithium](/CAS/GIF/917-54-4.gif)
917-54-4
174 suppliers
$52.10/25ml
![1-Cyanonaphthalene](/CAS/GIF/86-53-3.gif)
86-53-3
184 suppliers
$17.85/5g
![Naphthalene](/CAS/20180808/GIF/91-20-3.gif)
91-20-3
490 suppliers
$14.00/25g
![2-(NAPHTHALEN-5-YL)PROPAN-2-AMINE](/CAS/GIF/141983-61-1.gif)
141983-61-1
13 suppliers
$549.00/500mg