2-Octyl cyanoacetate synthesis
1synthesis methods
- Product Name: 2-Octyl cyanoacetate
- CAS Number:52688-08-1
- Molecular formula:C11H19NO2
- Molecular Weight:197.27
2-Octyl cyanoacetate was obtained by direct esterification of cyanoacetic acid with octan-2-ol in a 1:1 molar ratio in the presence of two/three drops of 2% concentrated sulphuric acid as a catalyst and toluene as solvent, to allow for the azeotropic removal of the reaction water.
Yield:-
Reaction Conditions:
sulfuric acid in water;toluene
Steps:
4
In this example, the following two 2-alkyl substituted cyanoacetates were obtained by direct esterification of cyanoacetic acid with a variety of alcohols in a 1:1 molar ratio in the presence of two/three drops of 2% concentrated sulphuric acid as a catalyst and toluene as solvent, to allow for the azeotropic removal of the reaction water.
References:
LOCTITE (R & D) LIMITED WO2008/50313, 2008, A1 Location in patent:Page/Page column 32