ChemicalBook CAS DataBase List 2-P-ANISYL-1,3-INDANDIONE

2-P-ANISYL-1,3-INDANDIONE synthesis

11synthesis methods

Product Name:2-P-ANISYL-1,3-INDANDIONE
CAS Number:117-37-3
Molecular formula:C16H12O3
Molecular Weight:252.26

87-41-2 Synthesis

87-41-2
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$6.00/10g

123-11-5 Synthesis

123-11-5
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$10.00/10g

117-37-3
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$70.00/1 g

Yield: 91%

Reaction Conditions:

with sodium methylate in methanol;ethyl acetate at 80; for 5 h;Cooling;

Steps:

2-(1-Trityl-1H-imidazole-4-yl)-1,3-indanedione (2)
General procedure: In a 2-neck round bottom flask, phthalide (3.75 g, 0.028 mol) and 1-trityl-1H-imidazole-4-carboxaldehyde (9.47 g, 0.028 mol) were added to ethyl acetate (25 mL). A cooled solution of sodium methoxide (10%, 50 mL) was added dropwise to the reaction mixture, and the mixture was stirred for 5 h at 80° C. After vacuum removal the solvent, the residue was poured into water and acidified by 1N hydrochloric acid to pH 4.5.The precipitate was filtered and washed with water and recrystallized from ethanol to afford 9.75 g (76 %) of crystalline product 2, mp 212-214° C (lit. 213-215° C).

References:

Karrabi, Behzad;Fakhraian, Hossein;Moghimi, Abolghasem [Organic Preparations and Procedures International,2019,vol. 51,# 4,p. 403 - 408]