2-(p-Methoxyphenyl)butyrophenone synthesis

7synthesis methods

Product Name:2-(p-Methoxyphenyl)butyrophenone
CAS Number:35258-39-0
Molecular formula:C17H18O2
Molecular Weight:254.32

93-58-3 Synthesis

93-58-3
481 suppliers
$16.00/25mL

104-01-8 Synthesis

104-01-8
523 suppliers
$6.00/10g

75-03-6
363 suppliers
$11.00/5g

35258-39-0
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Yield:35258-39-0 47%

Reaction Conditions:

Stage #1: 4-Methoxyphenylacetic acidwith sodium hexamethyldisilazane in tetrahydrofuran at 23; for 2 h;Inert atmosphere;
Stage #2: benzoic acid methyl ester in tetrahydrofuran at 23; for 2 h;Inert atmosphere;
Stage #3: ethyl iodidewith ethanolInert atmosphere;

References:

Li, Beryl X.;Le, Diane N.;Mack, Kyle A.;McClory, Andrew;Lim, Ngiap-Kie;Cravillion, Theresa;Savage, Scott;Han, Chong;Collum, David B.;Zhang, Haiming;Gosselin, Francis [Journal of the American Chemical Society,2017,vol. 139,# 31,p. 10777 - 10783] Location in patent:supporting information

24845-40-7 Synthesis