2-PIPERAZIN-1-YLNICOTINAMIDE synthesis
- Product Name:2-PIPERAZIN-1-YLNICOTINAMIDE
- CAS Number:87394-64-7
- Molecular formula:C10H14N4O
- Molecular Weight:206.24
84951-44-0
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$14.14/250mgs:
87394-64-7
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$55.00/250mg
Yield:87394-64-7 47%
Reaction Conditions:
with sulfuric acid at 100; for 19 h;
Steps:
[Intermediate 30]-2-(Piperazin-1-yl)pyridine-3-carboxamide
2-(piperazin-1-yl)pyridine-3-carbonitrile (250 mg, 1.33 mmol) was suspended in conc. sulfuric acid (5 ml) and stirred at 100° C. for 19 h. The reaction mixture was then diluted with water (30 ml), basified to pH 14 with aq. sat. NaOH and extracted with chloroform/isopropanol (9:1, 3×30 ml). The combined organics were concentrated under reduced pressure to afford the title compound as a tan solid (128 mg, 47%). 1H NMR (500 MHz, Chloroform-d) δ 8.55 (s, 1H), 8.40 (dd, J=4.8, 2.0 Hz, 1H), 8.31 (dd, J=7.6, 2.0 Hz, 1H), 7.09 (dd, J=7.6, 4.8 Hz, 1H), 5.90 (s, 1H), 3.22-3.16 (m, 4H), 3.07-3.01 (m, 4H). LCMS Method 4-Tr=1.03 min (ES+) (M+H)+ 207.4.
References:
US2018/127370,2018,A1 Location in patent:Paragraph 0415-0416
110-85-0
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10366-35-5
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87394-64-7
59 suppliers
$55.00/250mg