ChemicalBook CAS DataBase List 2-Piperazineethanol,(2R)-(9CI)

2-Piperazineethanol,(2R)-(9CI) synthesis

3synthesis methods

Product Name:2-Piperazineethanol,(2R)-(9CI)
CAS Number:660862-46-4
Molecular formula:C6H14N2O
Molecular Weight:130.19

857334-79-3 Synthesis

(R)-2-(4-benzylpiperazin-2-yl)ethanol-2HCl

857334-79-3
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660862-46-4
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Yield: 100%

Reaction Conditions:

with hydrogen;20% Pd(OH)2 on carbon in methanol under 2585.81 Torr;

Steps:

c
A Parr bottle was charged with a solution of 2- ( (R)-4-benzyl-piperazin-2-yl)-ethanol (2.87 g, 13.03 mmol) in 50 mL of MeOH. 500 mg of Pearlman's catalyst was added and the mixture was placed under 50 psi of H2 and agitated on a Parr shaker. After 1 hr, a large initial uptake of H2 was observed. The vessel was repressurized to 50 psi and agitated overnight. The bottle was purged of H2 and removed from the Parr shaker. The reaction mixture was filtered through diatomaceous earth and the filter cake was washed with MeOH. The filtrate was concentrated in vacuo to give quantitative yield of product. 1H-NMR : 300MHz, CDC13 5 3.82 (m, 2H); 3.02-2. 69 (m, 6H); 2.6-2. 52 (m, 1H) ; 1.62 (m, 2H).

References:

ASTRAZENECA AB WO2005/61510, 2005, A1 Location in patent:Page/Page column 15

D-Aspartic acid, N-(2-chloroacetyl)-, 1,4-dimethyl ester

1485770-18-0
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660862-46-4
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References

2-Piperazineacetic acid, 3,6-dioxo-4-(phenylmethyl)-, phenylmethyl ester, (2R)-

857334-77-1
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660862-46-4
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References