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2-Propyn-1-ol, 3-(3-methylphenyl)- synthesis

4synthesis methods
-

Yield:16035-11-3 94%

Reaction Conditions:

with copper(l) iodide;bis(triphenylphosphine)palladium(II)-chloride;triethylamine at 20; for 12 h;Inert atmosphere;Sonogashira coupling;

References:

Parmar, Dixit;Matsubara, Hiroshi;Price, Kieran;Spain, Malcolm;Procter, David J. [Journal of the American Chemical Society,2012,vol. 134,# 30,p. 12751 - 12757] Location in patent:supporting information; experimental part