2-Pyridinecarbonitrile,3-(methylthio)-(9CI) synthesis
- Product Name:2-Pyridinecarbonitrile,3-(methylthio)-(9CI)
- CAS Number:312904-91-9
- Molecular formula:C7H6N2S
- Molecular Weight:150.2
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Yield:312904-91-9 79%
Reaction Conditions:
in N,N-dimethyl-formamide at 20; for 2 h;
Steps:
96A.1
5 g (40.9 mmol) of 3-fluoropyridine-2-carbonitrile were dissolved in 40 ml of N,N-dimethylformamide. 3.2 g (45 mmol) of sodium thiomethoxide were then added slowly at room temperature. The mixture was stirred at room temperature for 2 h and then poured onto 500 ml of water. This resulted in the precipitation of a solid which was filtered off and washed with water. Drying under high vacuum gave 5.1 g (79% of theory) of the intermediate 3-(methylsulphanyl)pyridine-2-carbonitrile.
References:
TW2016/5831,2016,A Location in patent:Paragraph 0199