ChemicalBook CAS DataBase List 2-Pyridylacetic acid

2-Pyridylacetic acid synthesis

7synthesis methods

Product Name:2-Pyridylacetic acid
CAS Number:13115-43-0
Molecular formula:C7H7NO2
Molecular Weight:137.14

2739-98-2
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$11.00/1g

13115-43-0
89 suppliers
$77.00/5g

Yield:13115-43-0 100%

Reaction Conditions:

with water;potassium hydroxide in ethanol at 50; for 0.5 h;

Steps:

11 Example 11 Synthesis of 3- (pyridin-2-yl) quinolin-2 (1H) -one (3- (pyridin-2-yl) quinolin-2 (1H) -one)
1.65 g (10 mmol) of ethyl 2-pyridylacetate,Potassium hydroxide 0.67 g (12 mmol) in 13 mL ethanol,The mixture was added to 4.3 mL of water, and heated and stirred at 50 ° C. for 30 minutes.After completion of the reaction, the ethanol is distilled off,After extracting by adding diethyl ether,The aqueous layer is brought to pH 2 with 1N HClaq.The aqueous layer was concentrated to dryness with an evaporator.The obtained oily substance is crystallized with diethyl ether,The solid was filtered off and washed with diethyl ether.By vacuum drying the obtained solid,(2-pyridyl) acetic acid ((2-pyridyl) acetic acid)1.59 g (quant.)I got it. 411 mg (3.0 mmol) of the compound obtained,242 mg (2.0 mmol) of 2-aminobenzaldehyde,0.35 mL (2.5 mmol) of triethylamine,Add 570 mg (1.5 mmol) of HATU in 10 mL of DMF,Stir at 60 ° C. for 2 hours. After the reaction, water,Ethyl acetate is added for extraction, sodium sulfate is added and left to stand,After filtration, the solvent is distilled off with an evaporator,Purification on silica gel column(Developing solvent; ethyl acetate / hexane)Target compound53 mg(Yield 11.9%) was obtained.

References:

National University Corporation Osakakyoiku University of Education;Nippon Chemical Industry Co., Ltd.;Kodama, Hidehiko;Hatanaka, Atsushi Mochizuki;Hori, Kazushige;Tani Takashi, Futoshi JP2019/38987, 2019, A Location in patent:Paragraph 0147; 0148

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109-04-6 Synthesis