2-(quinolin-4-yl)-1-(pyridin-2-yl)-ethanone synthesis
2synthesis methods
- Product Name:2-(quinolin-4-yl)-1-(pyridin-2-yl)-ethanone
- CAS Number:7543-22-8
- Molecular formula:C16H12N2O
- Molecular Weight:248.28
Yield:7543-22-8 77.6%
Reaction Conditions:
Stage #1: C6H4NCH2CHCCH2with potassium hexamethylsilazane in tetrahydrofuran;toluene at -50; for 0.5 h;
Stage #2: ethyl-2-picolinate in tetrahydrofuran;toluene at -50 - 20;
References:
Gellibert, Fran?oise;Woolven, James;Fouchet, Marie-Hélène;Mathews, Neil;Goodland, Helen;Lovegrove, Victoria;Laroze, Alain;Nguyen, Van-Loc;Sautet, Stéphane;Wang, Ruolan;Janson, Cheryl;Smith, Ward;Krysa, Ga?l;Boullay, Valérie;De Gouville, Anne-Charlotte;Huet, Stéphane;Hartley, David [Journal of Medicinal Chemistry,2004,vol. 47,# 18,p. 4494 - 4506]
