ChemicalBook CAS DataBase List 2-thienyl)-3-butenyl]-, ethyl ester, (3R)-

2-thienyl)-3-butenyl]-, ethyl ester, (3R)- synthesis

9synthesis methods

Product Name:2-thienyl)-3-butenyl]-, ethyl ester, (3R)-
CAS Number:145821-58-5
Molecular formula:C22H29NO2S2
Molecular Weight:403.6

4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl methanesulfonate

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25137-01-3 Synthesis

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2-thienyl)-3-butenyl]-, ethyl ester, (3R)-

145821-58-5
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Yield:145821-58-5 75.5%

Reaction Conditions:

with potassium carbonate;potassium iodide in acetone at 20; for 72 h;

Steps:

11 Preparation and Purification of tiagabine hydrochloride: Example 11--through(RThe reaction piperidine-3-carboxylic acid ethyl ester and 1,1-bis (3-methyl-2-thienyl) -1-butene 4-sulfonate -)

At room temperature R-piperidine-3-carboxylate 62.0g (395mmol), 1,1-bis(3-methyl-2-thienyl)-4-methyl-1-butene sulfonate 133g (395mmol), anhydrous K₂CO₃ 200g (1.45mol), the mixture was stirred 3L and acetone KI 3.5g 72 hours, inorganic salts were removed by filtration, the filtrate was rotary evaporated to a red oil.

References:

CN103570703,2016,B Location in patent:Paragraph 0073; 0074