2-TRIFLUOROMETHYLCYCLOHEPTANONE synthesis
7synthesis methods
- Product Name:2-TRIFLUOROMETHYLCYCLOHEPTANONE
- CAS Number:60719-13-3
- Molecular formula:C8H11F3O
- Molecular Weight:180.17
Yield:60719-13-3 71%
Reaction Conditions:
Stage #1: 2,2,2-trifluroethylamine hydrochloridewith sodium nitrite in dichloromethane;water at 0; for 1 h;
Stage #2: cyclohexanonewith zirconium(IV) chloride at -78;
References:
Xu, Lei;Zhang, Qi;Xie, Qiang;Huang, Bei;Dai, Jian-Jun;Xu, Jun;Xu, Hua-Jian [Chemical Communications,2018,vol. 54,# 35,p. 4406 - 4409]
![Cycloheptene, 1-[(trimethylsilyl)oxy]-](/CAS/20210305/GIF/22081-48-7.gif)
