ChemicalBook CAS DataBase List 1H-Pyrazole-4-carbonyl chloride, 5-fluoro-1,3-dimethyl- (9CI)

1H-Pyrazole-4-carbonyl chloride, 5-fluoro-1,3-dimethyl- (9CI) synthesis

7synthesis methods

Product Name:1H-Pyrazole-4-carbonyl chloride, 5-fluoro-1,3-dimethyl- (9CI)
CAS Number:202476-26-4
Molecular formula:C6H6ClFN2O
Molecular Weight:176.58

1027991-91-8 Synthesis

5-FLUORO-1,3-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID

1027991-91-8
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$739.00/1g

1H-Pyrazole-4-carbonyl chloride, 5-fluoro-1,3-dimethyl- (9CI)

202476-26-4
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Yield:202476-26-4 95%

Reaction Conditions:

with thionyl chloride in dichloromethane; for 2 h;Reflux;

Steps:

1.5; 2.5; 3.5; 4.5; 5.5

The white solid V (0.28 g, 1.77 mmol) was dissolved in dichloromethane (10 mL), thionyl chloride (0.44 g, 3.54 mmol) was added, and the reaction was heated under reflux for 2 hours. After the reaction was completed, the reaction solution was cooled to room temperature, and the solvent was evaporated under reduced pressure to obtain yellow solid VI (5-fluoro-1,3-dimethyl-1H-pyrazole-4-carbonyl chloride, 0.30 g, yield 95%) ), the yellow solid VI was directly used in the next step without further purification.

References:

CN112174891,2022,B Location in patent:Paragraph 0107; 0114; 0139; 0145; 0153; 0159; 0167; ...