2-[(5-BROMO-2-THIENYL)CARBONYL]BENZENECARBOXYLIC ACID synthesis
- Product Name:2-[(5-BROMO-2-THIENYL)CARBONYL]BENZENECARBOXYLIC ACID
- CAS Number:205644-06-0
- Molecular formula:C12H7BrO3S
- Molecular Weight:311.15
Yield:-
Reaction Conditions:
aluminium trichloride in 1,1-dichloroethane;
Steps:
42 Synthesis of (R)-1-(α-phenylethylamino)-4-(4-methyl-2-thienyl)phthalazine (Compound No. 189 in Table 1)
Example 42 Synthesis of (R)-1-(α-phenylethylamino)-4-(4-methyl-2-thienyl)phthalazine (Compound No. 189 in Table 1) 1.90 g of phthalic anhydride and 3.58 g of aluminum chloride were dissolved in 40 ml of dichloroethane, and 2-bromo-3-methylthiophene was added dropwise to the solution at room temperature. After stirring the solution for 4 hours, the reaction solution was poured into a 1-N hydrochloric acid under cooling with ice, and extracted with chloroform. By purifying the extract by silica gel chromatography (eluent: chloroform, ethyl acetate), 1.70 g of o-(5-bromo-2-thenoyl)benzoic acid was obtained.
References:
US5462941,1995,A
