ChemicalBook CAS DataBase List N-(3-Chloro-4-fluorobenzoyl)-4-fluoro-4-N-(3-Chloro-4-fluorobenzoyl)-4-fluoro-4-hydroxymethylpiperidine

N-(3-Chloro-4-fluorobenzoyl)-4-fluoro-4-N-(3-Chloro-4-fluorobenzoyl)-4-fluoro-4-hydroxymethylpiperidine synthesis

3synthesis methods

Product Name:N-(3-Chloro-4-fluorobenzoyl)-4-fluoro-4-N-(3-Chloro-4-fluorobenzoyl)-4-fluoro-4-hydroxymethylpiperidine
CAS Number:208111-36-8
Molecular formula:C13H14ClF2NO2
Molecular Weight:289.71

(3-Chloro-4-fluoro-phenyl)-(1-oxa-6-aza-spiro[2.5]oct-6-YL)-methanone

208111-51-7
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N-(3-Chloro-4-fluorobenzoyl)-4-fluoro-4-N-(3-Chloro-4-fluorobenzoyl)-4-fluoro-4-hydroxymethylpiperidine

208111-36-8
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Yield:208111-36-8 50%

Reaction Conditions:

with pyridine hydrogenfluoride in dichloromethane;a) -10 deg C, 15 min, b) RT, 16 h;

References:

Vacher, Bernard;Bonnaud, Bernard;Funes, Philippe;Jubault, Nathalie;Koek, Wouter;Assié, Marie-Bernadette;Cosi, Cristina;Kleven, Mark [Journal of Medicinal Chemistry,1999,vol. 42,# 9,p. 1648 - 1660]

65055-17-6 Synthesis

65055-17-6
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208111-36-8
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References

223632-64-2 Synthesis

N-(3-chloro-4-fluorobenzoyl)-piperidine-4-one

223632-64-2
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208111-36-8
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References